PSY492H1 Lecture Notes - Lecture 7: Proteasome, Ubiquitin, Rna Interference
Document Summary
5 primary papers and do a literature review. Discussion (3-5 pages) states question you want to address, method, schematic figures to explain design of experiment and expected results(general and fake figure in appendix, not in page requirement) Get diverse studies related to a particular topic. Justification of why you choose method you choose. Could track molecular system more short term than long term. Synaptic molecules that support memory trace are short lived compared to the actual memory. Ampars open, conformation change, open and close, then eventually structure becomes degraded. It still functions but needs to be replaced by something new. Old proteins need to be cleared and be replaced by new ones. Amount of synthesized protein determines level of synaptic potentiation needs to be controlled. Protein degradation by ubiquitin proteasome system (ups) controls amount of proteins which regulate transcription and translation. If speed of both are controlled at the same level, number of proteins sitting on the spine is maintained.
