MICR 302 Lecture 8: MICR 302 A01 - Jan 29th
7 Feb 2018
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> consensus (not absolute) dif sequences may have different strengths of binding. We can alter affinity of sigma factor by altering sequence or spacing in -10 and -35. Core has all units necessary for satalysis. Requires sigma to bind to promoter (unit 2 and 4) 2 = -10, 4= -35 (where dna binds to core polymerase) Each one has its own regulon: a number of genes promoted in similar way with different promoter (ex: all genes affected by cap binding. We can vary quantity and affinity of dif sigma factors > competing for polymerase, will favour some over others. Can see levels rise or fall under certain environmental conditions. Can drastically alter genes being transcribed based on sigma affinity and abundance. Factors present at all times (may be low, but still expressed) euks. vs. proks. euks: Ex: subtilis uses dif factors than e coli gene regulation:
