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Lecture

PhosphoHexose

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Department
Biological Sciences
Course
55-140
Professor
Habetler
Semester
Fall

Description
GLYCOLYSIS: 1. Hexokinase/Glucokinase glucose  G6P regulatory point induced fit model 2. PhosphoHexose G6P  F6P Isomerase 3. PhosphofructoKinase-1 F6P  F1,6BP **KEY regulatory point** (PFK1) 4. Aldolase F1,6BP  DHAP + GAP 5. Triose Phosphate DHAP  GAP Isomerase 6. GAP Dehydrogenase GAP  reduces NAD  NADH (GAPDH) 1,3Bisphosphoglycerate (NAD must be replenished) 7. Phosphoglycerate Kinase 1,3BPG + ADP  **first ATP generating ATP + 3PG step** highly exergonic and coupled with step 6 8. Phosphoglycerate Mutase 3PG  2PG 9. Enolase 2PG  PEP (phosphoenolpyruvate) 10. Pyruvate Kinase PEP + ADP  **regulated step** Pyruvate + ATP RBC’s: 1,3 BPG  2,3 BPG: binds hemoglobin and reduces oxygen affinity 2,3 BPG levels are elevated at high altitude, late pregnancy 2,3 BPG  3PG **ATP generating step is circumvented** (step 7 skipped) HEXOKINASE GLUCOKINSAE low Km easily saturated high Km G6P inhibition no inhibitions uninducible inducible expression
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