Anatomy and Cell Biology 3309 Lecture Notes - Lecture 8: Keratan Sulfate, Metastasis, Fibrous Joint

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During development, provides a model for bone. Provides a template for the growth of long bones. It is required for a process called endochrondral ossification. In joints, acts as a shock-absorber: transfer load applied to joints. In attachments, has strength (fibrocartilage: enthesis (connective tissue between tendon or ligament and bone) ligaments link onto bone. Allows for changes in compliance between tissues. Provides tissue flexibility (elastic cartilage: found in external ear and vocal cords. Cartilage is composed of cells, ecm fiber components (type ii collagen), ecm non fiber components (abundance of proteoglycans) No blood vessels: nutrients and waste controlled by diffusion, causes problems: if cartilage is damaged alone (without damage of bone), there is no inflammatory response, body has no intrinsic way of healing cartilage defects. Low cell-cell contacts: contains very low amount of cells in comparison to the amount of ecm, 10% of tissue is composed of cells.

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