Anatomy and Cell Biology 3309 Lecture 15:

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teallion850

19 Aug 2019

School

Western University

Department

Anatomy and Cell Biology

Course

Anatomy and Cell Biology 3309

Professor

Martin Sandig

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Document Summary

Skeletal muscle attached to bones: contraction of the contractile units allows us to move our bodies, has to cross a joint, to get movement. 1 muscle fiber/myofiber = 1 skeletal muscle cell: made up of tons of myofibrils. Perimysium: lct enclosing each fascicle more well developed lct than endomysium: difference: Perineurium formed blood-nerve-barrier, so blood vessels were on the outside. Perimysium actually houses the blood vessels & nerves. Epimysium: dict enclosing the whole muscle: muscle is attached to bone, by a tendon, tendons (drct) are formed by all three layers coming together at edge of the muscle. In cross section, stippled appearance is due to the arrangement of the myofibrils. Skeletal muscle fiber ultrastructure: myofibril: chain of sarcomeres. Lots of mitochondria bc muscle contraction is very energy dependent. Striated appearance due to dark a band and light i band, that alternate: bands are due to overlap or lack of overlap of contractile proteins, w/in the contractile unit.

Related Questions

1) a) Describe the structure of vertebrate skeletal muscle using ALL the following words: myofilament, muscle fiber, sarcoplasmicreticulum, T tubules, myofibrils, nerves, blood vessels, connective tissue. Do not simply define these terms, but describe how they are arranged to form muscle.

b) In long bones such as the femur and humerus, where is spongy bone found in relation to compact bone?

c) Describe 3 ways vertebrate skeletal muscle differs from smooth muscle in terms of its structure (functions do not count).

silverbeaver496

[25 points]

You have recently isolated and cloned the gene and cDNA for a novel

calcium binding protein from fruit fly muscle tissue. Initial comparisons of the sequence with

other similar proteins from Frog, Rat, and Cow indicate that this is a highly conserved protein.

Your major model system for studying the development and function of skeletal muscle is

mouse. Design and describe a series of experiments that will allow you to clone the mouse

cDNA and gene from mouse muscle tissue (remember you already have clones for fruit fly, frog,

rat, and cow). How could you determine the mRNA expression level of this gene in mouse

muscle?

Question 2) [25 points]Define Genomics Proteomics, and Bioinformatics and discuss how they are used for studying gene expressio

fuchsiacricket487

Where would you expect to find fenestrated capillaries? (More than one answer may be correct)

1. Thyroid

2. Skeletal muscle

3. Cardiac muscle

4. Spleen

Anatomy and Cell Biology 3309 Lecture 15:

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