Anatomy and Cell Biology 3309 Lecture Notes - Lecture 2: Neurofibrillary Tangle, Intermediate Filament, Cleavage Furrow
3 Dec 2014
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Document Summary
Originate at centrosome/mtoc (contains centrioles) and initiate from tubulin rings. Consist of and tubulins, forming dimers. Look like hollow tubes or railroad tracks in micrograph. Have associated proteins called maps that link mt"s to other structures. Polarized (+) and (-) ends: form centrioles and basal bodies (same structure actually) 9 triplets of mt arranged in a ring. 2 centrioles per cell found 90 degrees to each other. Can determine what stage of cell cycle the cell is in by looking at the. # of centrioles and their location in the cell. Found in close proximity to nucleus, in association with golgi. Basal body is same as centriole, but associated with pm and have a cilia/flagella projecting from it: axonemes of cilia and flagella cell movement, movement of extracellular fluid. Intracellular transport of cell components via motor proteins. Can use antibodies to visualize mt because antibodies bind specifically to epitopes. Mt poisons would interrupt activities like intracellular transport + movement.
