Anatomy and Cell Biology 4429A Lecture 1: Protein Folding

• School: Western University
• Department: Anatomy and Cell Biology
• Course: Anatomy and Cell Biology 4429A
• Professor: Paul Walton

Document Summary

Objectives: the steps by which a protein folds, the problem of protein folding within a cell, the enzymes which promote correct protein folding, diseases which result from the failure to fold a protein correctly. Each amino acid is bound by a peptide bond between the. Because it is a single bond, there is a huge range of rotations and shapes possible for a protein. Using x-ray crystallography, he imaged the -heli(cid:454) a(cid:374)d -sheets. Linus pauling was the only person to win two nobel. Prizes in two different fields, single handedly (marie curie as well, but she worked with someone else) As the primary structure comes out, it immediately starts forming the secondary structures. Appears like a brush with the side chains sticking out of the coiled structure. Has side chains sticking out in the front and the back in an alternating pattern. So there can be two sets of information that can be used in different combinations.