Anatomy and Cell Biology 4461B Lecture Notes - Microtubule, External Beam Radiotherapy, Photodynamic Therapy
13 Jun 2012
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Document Summary
Prostate cancer quick facts: most common cancer in canadian men; afflict 1/7, 1/27 will die, has one of the highest survival rates (5 year survival is 100% for localized and 30% for metastatic cancer in north america) Age: most important risk for prostate cancer, rarely occurs in men under 40. Ethnicity: black men have the highest incidence, asian men have the lowest. Family history: men with a brother or father diagnosed with prostate cancer at age 50 are 2-fold more likely, men with more than one first degree relative diagnosed are 8-fold more likely to get prostate cancer. Diet and lifestyle: increased risk is associated with high-saturated fats, red meats, low fruits, low veg- etables, low fish and low soy. Vitamin d, omega-3, calcium and non-steroidal anti- inflammatory agents are implicated in reduced incidence. Obesity: associated with high-grade cancers because of lower testosterone. Elac2/hpc2: increased frequency of tmprss2:erg oncogenic gene fusion occurs in moderate to poorly differentiated prostate cancers.
