Anatomy and Cell Biology 4461B Lecture Notes - Nitric Oxide, Chronic Myelogenous Leukemia, Carcinogen
13 Jun 2012
School
Department
Professor
Document Summary
What is translational cancer research: translational research transforms scientific discoveries arising from laboratory, clinical, or population studies into clinical applications to reduce cancer incidence mobidity and mortality. Basic science discoveries: promising molecule or gene target, candidate biomarker, epidemiological finding. Late translation: phase iii trials: does it work better than the standard, regulatory approval, commercialization and production, phase iv trials for additional uses, costs money to education the public and the health sector. Dissemination: might lead to new drug or diagnostic tool disseminated to health care sector and public. Tumour model: cells, tissues, or animals used to study the development and progression of cancer, and to test new treatments before they are given to humans. Xenografts (1970s): when cells of one species are implanted into a different species us- compromised mice (nod/scid, nude). Orthotopic site better mimic tumour en- ing immune vironment.
