Anatomy and Cell Biology 4461B Lecture Notes - Gadolinium, Ct Scan, Aconitase
Document Summary
Jl lecture 2: the role of imaging in prostate cancer. Interaction with host blood cells: clonal expansion, growth, diversification and angiogenesis, migration through the basement membrane. 5: formation of tumor embolus, arrest in capillaries and adhesion to basement membrane, extravasation, metastatic deposit and growth in secondary organ. Metastasis is extremely inefficient; less than 0. 01 of cell that originated from the primary tumor actually metastasize. Models of prostate cancer: other than man, dog is the only animal known to have spontaneous high grade pin and prostate cancer and have similar disease characteristics including age of onset, metastasis and androgen independence. Animal models: xenografts - can be subcutaneous or orthotopic (in the prostate). For ex. haploinsufficiency of pten is an early event in prostate tumorigenesis, resulting in the development of high-grade pin. If you in- ject tumor cells in the chick embryo, can see a dramatic increase in blood vessel growth.