Biochemistry 2280A Lecture Notes - Lecture 24: Xeroderma Pigmentosum, Cervical Cancer, Basal Lamina
30 Dec 2017
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Document Summary
Molecular basis of cancer: characterized by genetic and biochemical defects, biochemistry and molecular biology provide avenues for cures. Tumour types: benign- encapsulated, won"t spread since it"s stuck in a capsule, can be removed surgically, malignant- not encapsulated, can spread to other parts of the body, movement of malignant tumour= metastasis. Susceptibility to cancer can be inherited: retinoblastoma (eye), xeroderma pigmentosa (skin), some forms of breast, prostate, ovarian, and intestinal cancers, dna damaging agents cause cancer, radiation: uv, xrays, chemical mutagens. Avoidable causes of cancer: agents that cause dna damage (radiation, mutagens) Increase cell division- more cells dividing= more chance of something going wrong: cause inflammation, certain viruses, hepatitis (liver cancer, hpv (cervical cancer and others, hiv (kaposi sarcoma, non-hodgkins lymphoma, perhaps lead to enhanced cell proliferation. Smoking is the single most preventable cause of cancer. Cell cycle: g1- increase cell content, proteins, lipids, etc. Dna is not doubled: g2- cell checks to see if duplication has gone correctly.
