Biochemistry 2280A Lecture Notes - Lecture 24: Contact Inhibition, Fusion Protein, Chromosome
30 Jan 2018
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Unit 6: molecular basis of cancer lesson 24: cancer (dec. 1st 2017) Dna damaging agents cause cancer: radiation (uv and x-rays, chemical mutagens (benzene), dna damage = cancer causing. Types of cancer causing genes: oncogenes a mutant of a normal gene whose presence causes cancer, genes that something has gone wrong in, acts dominantly gain of function. If transcription factors lose control: dna repair proteins (xeroderma pigmentosa (xpc), cells accumulates more and more dna damage and thus mutation to key genes. Inaccessibility of the tumour to drug blood-brain barrier (hard to get chemicals into here). Ide(cid:374)tifyi(cid:374)g drugs for the (cid:862)u(cid:374)drugga(cid:271)le(cid:863) genome targets: profiling cancer cell genomes know specifically what defect the cancer has on the body, sequencing the genome to see (cid:449)hat"s goi(cid:374)g o(cid:374), prevention smoking, environmental issues, etc. Studies of molecular structure and function are providing cures for cancer: gleevac as a treatment for chronic myeloid leukemia.
