Biochemistry 2280A Lecture Notes - Dna Mismatch Repair, Dna Replication, Cyclobutane
Document Summary
Describe and differentiate between the different kinds of commonly observed dna damage. Predict which repair mechanism will be used to repair a particular instance of dna damage. Predict the consequences of dna damage that is not repaired before the next round of replication. Describe the role of translesion dna polymerases as they relate to. Dna damage = any unintended physical or chemical change in dna or its sequence. Dna molecules are huge and are prone to damage. To try to avoid changes in nucleotide sequence, cells have developed mechanisms for repairing dna damage. Mutations are not always bad, occasionally you get beneficial one, but the organism doesn"t know whether or not it will be beneficial. The cell wants to conserve the sequence of dna. Causes of dna damage: copying mistakes: dna polymerase makes an error about once every 107 nucleotides.