Biochemistry 3386B Lecture 4: Deroo Lecture 4 Notes
Document Summary
Describe an overall view of cell signaling. Specify how steroid hormones signal. Iden=fy sequence and loca=on of hormone response elements. Appreciate the dynamic nature of steroid hormone receptor movement. Cell- cell communica=on & signaling signaling cell target cell target cell signaling cell. Types of extracellular signaling molecules. Most cells are exposed to hundreds of di erent signals. Signals may originate from: extracellular uid, extracellular matrix, neighbouring cells. Insulin adrenaline (from tyrosine) nitrous oxide aldosterone. Funcaon s=mulates glucose uptake increases blood pressure, heart rate, and metabolism smooth muscle cell relaxa=on regulates blood pressure. Signal transducaon: mechanism that converts a mechanical/ chemical s=mulus to a cell into a speci c cellular response. Typically, it starts with a signal to a receptor, and ends with a change in cell func=on. Receptor proteins: whether a cell responds depends on whether it expresses a signal- speci c receptor. Cells can signal over long and short ranges. Receptor binding can induce many di erent cell responses.