Biochemistry 2280A Lecture Notes - Lecture 8: Hydrophile, Multiple Drug Resistance, Integral Membrane Protein
14 Dec 2016
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Document Summary
Describe the different functions membrane proteins can perform. Explain in basic terms how polar or charged molecules can move across membranes. Contrast the different ways in which proteins can be associated with a lipid bilayer. Describe the diffusion behaviour of proteins in biological membranes. Explain the practical challenges membrane proteins present for biochemical study. 50% proteins, 50% lipids, a few carbohydrates. Implication: membranes are not just passive barriers to polar molecules. Lots of things are charged or very polar, and they won"t want to go through the membrane: this is why we have transporters and channels. Anchors give the membrane shape and structure and organization (not necessarily important) Receptor molecules give a response to the red circle problem" (ex: give signal to other things and those things give response. Transporters: speci c binding site, conformational changes during transport. Yellow circles will be on one side of the membrane. Then acts, changes shape and releases on the other side.
