Biochemistry 2280A Lecture Notes - Lecture 17: Exact Sequence, Pribnow Box, Escherichia Coli
13 Feb 2017
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Document Summary
In any cell type less than 10000 are expressed. Human genome encodes 21000 protein encoding genes. Expression of correct genes is essential for growth and differentiation. Brain and liver cells have same genes but don"t express the same proteins. Most diseases are due to altered expression of one or more genes. By therapeutically manipulating gene expression, have potential to reverse disease. Information flow from dna transcribed to rna translated to protein. Rna processing: rna editing, 5"caping, 3"polyadenylation, splicing, mrna export from the nucleus to the cytoplasm, translation (initiation, elongation, termination, mrna degradation. The amount of mrna found in a cell depends on. Both its rate of synthesis and its rate of decay: protein modification. Cleavage (insulin is only active when peptide is cleaved: protein degradation. The amount of protein in a cell depends on its rate of synthesis and rate of decay. There"s an rna step in the process from dna to protein gene expression.
