Biochemistry 2280A Lecture Notes - Lecture 9: Hydrolysis, Blood Sugar, Skeletal Muscle

• School: Western University
• Department: Biochemistry
• Course: Biochemistry 2280A
• Professor: Boffa/ Mc Lauchlin/ Brandl

Document Summary

Identify the different metabolic fates of glucose-6-phosphate, and how these pathways are related. Explain in general terms how glycogen is synthesized and degraded. State the net reactions of glycolysis and gluconeogenesis (including stoichiometries) State the metabolic circumstances under which glycogen synthesis, glycogen degradation, glycolysis, and gluconeogenesis are favoured, without memorizing individual regulators. Describe the purpose of fermentation, identify circumstances under which it is used, and give the products of the two main fermentation pathways. Explain the purposes of the pentose phosphate pathway, and identify the ultimate fates of carbon atoms that enter this pathway. Explain in general terms how pathways that carry out opposite processes (e. g. , glycolysis and gluconeogenesis) can both be energetically favourable. Addition of glucose-1-phosphate to glycogen is catalysed by glycogen synthase. Glycogen (n residues) + g1p + utp glycogen (n + 1 residues) + udp + 2 pi. Similar hydrolysis reaction with similarly -ve g value (atp equivalent) Branching enzymes creates the branch points found within glycogen.