Biochemistry 2280A Lecture Notes - Lecture 10: Pyruvate Dehydrogenase Complex, Inner Membrane, Decarboxylation
14 Dec 2017
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Outer membrane lipid bilayers with big pores embedded: keeps out large polar molecules, not a barrier to small polar molecules. Small molecules can cross through the pores of the outer membrane. Matrix: where the pyruvate is transported to, space that is enclose by inner membrane. 2 stages: decarboxylation of pyruvate, citric acid cycle. Sh can be reacted with things (fatty acids) Pyruvate dehydrogenase complex: 60 polypeptide chains, 3 different enzymes. This is an irreversible reaction: site of regulation, same enzyme does not catalyze backwards, we don"t have an enzyme that will catalyze backwards no reverse reaction. Can go from carbohydrate to fatty acid but cant go from fatty acid to carbohydrate: irreversible, this enzyme is regulation, products (acetyl-coa and nadh) are competitive inhibitors of the enzyme. When products build up want to shut process down. 2 - citric acid cycle (tca cycle, krebs cycle): Need to know what goes in and what goes out.
