Biochemistry 2280A Lecture Notes - Lecture 19: Thalassemia, Nuclear Membrane, Rna Splicing
23 Dec 2017
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Processes for primary rna to become translatable mrna. These are concerted processes (they happen at the same time as transcription: 5" g-cap. Adds 7-methylguanosine at the 5" end of rna as soon as its made (unique 5"-5" linkage) 1st nucleotide is a triphosphate, a guanosine gets added to this triphosphate. Acts as a sign that the rna is intact (if it were degraded in nucleus, the 5" cap would. Note that only rna"s to be translated into protein need a 5" cap. trna/ rrna"s don"t need 5" caps because they are not translated. Allows rna to be exported from nucleus. Helps to stabilize mrna from being degraded in cytoplasm. Acts as translational signal: polyadenalyation (poly a tail) Adding a long string of a to the 3" end of rna. On each rna, after the stop codon, there is a polyadenylation signal (aauaaa) this signals a polyadenylation machinery to come in a clip 30 bases later.
