Biochemistry 2280A Lecture Notes - Lecture 13: Ribose, Diabetes Mellitus Type 1, Peptide

• School: Western University
• Department: Biochemistry
• Course: Biochemistry 2280A
• Professor: Bonnie Mac Lachlan

Document Summary

High insulin, therefore glucose broken down by glycolysis. When atp accumulates, citric acid cycle slows down. Insulin tells body to store things like glycogen and triacylglycerol. Lots of building blocks for biosynthesis (ex: protein synthesis) Breakdown of triacylglycerols (in adipocytes) to fatty acids/glycerol (further made into ketone bodies for export to other tissues, and eventually glucose for atp) Muscle picks up ketone bodies from the liver. Body behaves like you are under fed, so glucose levels stay high. Cells producing insulin in pancreas lose effectiveness over time (less insulin produced) Tissues (cid:272)a(cid:374) (cid:271)e(cid:272)o(cid:373)e i(cid:374)suli(cid:374) resista(cid:374)t, therefore do(cid:374)"t rea(cid:272)t as (cid:373)u(cid:272)h to i(cid:374)suli(cid:374) Develops later on in life, usually do to over eating/not exercising/old age. Always beta configuration to number the carbons, number the base first and then go to the sugar using (cid:862)pri(cid:373)e(cid:863) Ribonucleotide (cid:862)tide(cid:863) = (cid:374)u(cid:272)leoside (cid:449)ith at least 1 phosphate (cid:894)e(cid:454): (cid:272)(cid:455)tidi(cid:374)e (cid:373)o(cid:374)ophosphate(cid:895) Purines: two rings: adenine (base) adenosine (nucleoside, guanine (base) guanosine (nucleoside)