Biochemistry 2280A Lecture Notes - Lecture 11: Electrochemical Potential, Active Transport, Stoichiometry
30 Jan 2018
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Unit 2: energy metabolism lesson 11: oxidative phosphorylation (oct. 20th 2017) Cofactors: protein-bound non-protein chemical, metal ions or organic molecules, coenzyme organic cofactor, often a reaction substrate, can be changed in a reaction cycle, prosthetic group tightly bound coenzyme, could be covalently bound as well, permanently attached. Overview of electron transport: electrons from nadh and fadh2 are used to move hydrogens over to other side, then water is made from o2, h+ gradient = potential energy. Larger negative free energy = the more likely the process is used for proton movement: nadh has positive free energy, passes to o2 because it has a stronger affinity for it, energetically favourable, used to pump protons. Isoalloxazine ring: aromatic ring structure that can pick up two electrons, usually associated with a protein, do not float around by themselves. Iron-sulfur centres: each center can accept one electron (fe3+ fe2+, have different number of irons and sulfurs, each center only accepts one electron, ubiquinone:
