Biochemistry 2280A Lecture Notes - Lecture 11: Allosteric Regulation, Glutamine, Metabolic Pathway
22 Oct 2018
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Biochemistry lecture 11 october 5, 2018. Topic 8 fundamental concepts in metabolism: gibbs free energy (g) G is affe(cid:272)ted (cid:271)y : properties of the molecules, reaction conditions (temperature, pressure, concentration, energetically favourable reactions. Spontaneous reactions have reactants with more energy than products (- g) therefore the forward reaction is more prominent than the reverse reaction. Po(cid:374)ta(cid:374)eous does(cid:374)"t (cid:373)ea(cid:374) fast: reaction at equilibrium. The rate is the same in both directions (equilibrium) No net reaction: energetically unfavourable reaction. Reactants are more favourable than the products. Products have more free energy than reactants. Reaction shifts to counteract changes in concentration. Rea(cid:272)tio(cid:374) is (cid:862)reversi(cid:271)le(cid:863) enzymes catalyzes reaction (they are bidirectional) If you take away some reactants, the system will shift toward the reactants to balance out the equilibrium (cid:862)irreversi(cid:271)le(cid:863) rea(cid:272)tio(cid:374)s. G is extremely negative (exothermic reactions where the backwards reaction hardly. Insensitive to changes in concentration every happens this is why irreversible is in quotes)
