Biochemistry 2280A Lecture Notes - Lecture 10: Acetyl-Coa, Mitochondrial Matrix, Lipid Bilayer
20 Aug 2019
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Document Summary
The oxidation of pyruvate into co2 under aerobic conditions. Two membranes: outer membrane, lipid bilayer with aqueous pores. Allows small polar molecules to easily cross without the need for transporters (under 5000 daltons, i. e. pyruvate: permeable to most solutes of low molecular weight. Inner membrane: lipid bilayer, impermeable to ions and charged molecules (require protein channels, folded to form cristae, increasing its surface area. The space enclosed by the inner membrane is called the matrix. Mitochondrial matrix: space enclosed by the inner membrane, contains proteins, extrachromosomal dna, and ribosomes. Mitochondrial genome: circular genome containing 37 genes, encode some of the subunits involved in oxidative phosphorylation as well as the rna required for translation of these molecules. Its believed that mitochondria evolved from bacteria that lived symbiotically in primitive cells: both bacteria and mitochondria have 2 membranes because they carry their own. Dna evidence that mitochondria derived from bacteria: both reproduce by dividing.
