Biochemistry 2280A Lecture Notes - Lecture 17: Consensus Sequence, Pribnow Box, Rna Editing

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Human genome has very little protein encoding genes --> ~21, 000 genes. Brain and the liver cells have the same genes but they do not express the same proteins. Thus, gene expression is dependent on the type of cell. Human liver has lots of heavy and basic proteins whereas the brain has a lot of average weight isoelectric proteins. But the genomes in both cell types are the same. Housekeeping genes, of course, are expressed in all cell types as they are fundamental. In many cases, diseases are due to altered gene expression. If one can therapeutically manipulate gene expression, we have the potential to prevent or reverse disease. Audio recording started: 2:42 pm november 9, 2016. Central dogma and points of regulation in gene expression. Transcription (dna -> rna) can be regulated at 3 different steps. Rna editing; 5" capping (only eukaryotes); splicing; 3"polyadenylation.

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