Biochemistry 2280A Lecture Notes - Lecture 34: Chromosome Segregation, Telophase, Prometaphase

• School: Western University
• Department: Biochemistry
• Course: Biochemistry 2280A
• Professor: Mclachlin

Document Summary

The cell cycle, ensures 3 things: chromosome replication, chromosome segregation, cell division. Have to occur normally and precisely to ensure two functional daughter cells are created, otherwise may contain wrong number of chromosomes which may lead to a syndrome. Incubate cells in radioactive phosphate, most of the phosphate will be used up for. Dna synthesis expose radiographic film and the radioactivity fogs the film. The eukaryotic cell cycle usually consists of four phases, including g1 and g2 which are gaps separating the s and m-phases. G-phases: cell growth, evaluating if the duplication of chromosomes has been done accurately quality control, g0 = if cells are not exposed to nutrients, can sit for years and will not proliferate or replicate. Introduce a mutation into a gene, to break the process and then reconstruct: biochemical approach could identify the process if there was a large supply of cells undertaking the transition at the same time.