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Lecture 2

Biochemistry 2280A Lecture Notes - Lecture 2: Logarithm, Acid Dissociation Constant, Garland Science


Department
Biochemistry
Course Code
BIOCHEM 2280A
Professor
Susan Meakin
Lecture
2

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Lecture'#2:'Amino'Acids'
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Introduction*to*calculating*the*charge*of*an*amino*acid*
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A'protein’s'properties'in'a'solution'depends'on'the'protein’s'net'charge''
Three'parts'of'an'amino'acid'can'carry'a'charge'in'solution:'
; Amino'group'
; Carboxylic'acid'group'
; Side'chain'(for'some'amino'acids'only)'
Protons'in'solutions'move'continuously'(back'and'forth'between'molecules)'
To*calculate*the*charge*of*a*single*amino*acid,*we*need:*
1) The'number'protons'available'in'solution!'pH'
2) The'strength'of'the'group'to'attract'protons!'pKa'
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The*pH*Scale*
*
pH:'a'scale'to'measure'the'acidity'or'how'basic'a'solution'is,'it'ranges'from'0;
14'where'0'is'very'acidic'and'14'is'very'basic'
Neutral'is'pH'of'7'
pH=;log[H+]'
[H+]='10;pH''
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Units:'
[H+]'is'in'mol/L'or'M'
pH'has'NO'units'
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