Biochemistry 2280A Lecture Notes - Lecture 16: Triglyceride, Adipocyte, Lipase

• School: Western University
• Department: Biochemistry
• Course: Biochemistry 2280A
• Professor: Chris Brandl

Document Summary

Topic 16: acetyl coa ii: fatty acids, ketone bodies, and biosynthesis. Hormone-sensitive lipase degrades triacylglycerols to make glycerol and fatty acids. Insulin (lot of sugar don"t need to break down fatty acids) would deactivate lipase and glucagon (low sugar so need to break down fatty acids) actives lipase. Fatty acids need to be attached to coa to gain entry into the matrix. Fatty acyl-coa is transported into the mitochondrial matrix. Net reaction of acyl-coa with 2n carbons: Oxidation of unsaturated fatty acids (has double bonds) yields fewer fadh and may. Oxidation of odd-chain fatty acids yields one propionyl-coa which enters tca as succinyl- 2 gives electrons to q to make qh. How acetyl-coa is transported from liver to other tissues. Need a way to get the acetyl-coa into the cytosol. Tricarboxylate transport system moves actyl-coa into cytosol, consuming atp and nadh but making nadph. Fatty acids are stored as triacylglycerols or used to make membrane lipids.