Biochemistry 2288A Lecture Notes - Lecture 21: Start Codon, Transfer Rna, Ribosome
Document Summary
The conversion of the information in rna into protein represents translation of the information into another language that uses different symbols. There are 4 different nucleotides in mrna but 20 different amino acids in a protein. The genetic code (cid:494)spells(cid:495) out the amino acid sequence in (cid:885)(cid:499)letter(cid:499) (cid:498)words(cid:499) called codons. A one letter code with a,g,u,c would provide: 4 codons. A two letter code would provide 4*4= 16 codons. A three letter code would provide: 4*4*4= 64 codons. As there are 20 amino acids, a 3 letter code is sufficient. 1. universal (almost) code evolved once: non-overlapping (overlapping would place significant restriction on what amino acid residue could follow each other) Increases the chance of a functional protein in the case of a single base mutation. trna. Bring the amino acids to the growing polypeptide chain. All trnas have a similar structure (clover shape) Step loop structure due to internal base pairing , in 3d trna looks like a l.