Biochemistry 2288A Lecture Notes - Lecture 1: Central Dogma Of Molecular Biology, Side Chain, Hydrophile

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The central dogma of biology refers to the way that genetic information is stored and retrieved in living cells. The classic relationship is dna --> rna --> protein. The information stored in dna is the genotype (the sum of inheritable potential) and when this information is translated into rna and protein, a phenotype (the sum of observable characteristics) is produced. Properties of the side chain determine a protein"s character. Phosphorylation of these 3 amino acids can have a dramatic effect on protein function. We assume phosphorylation is essential to function. i. Replace amino aid thought to be phosphorylated with alanine (charge = 0). What happens to the function of the protein? ii. Replace amino acid with an acidic amino acid, like aspartic acid (charge= -1). Describe the bond that holds amino acids together to form proteins. Proteins are made from building blocks called amino acids, which are strung together in long polymer chains.

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