Biochemistry 3381A Lecture Notes - Lecture 10: Retinal Ganglion Cell, Lipid Bilayer Fusion, Dynamin-Like 120 Kda Protein
20 May 2020
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Document Summary
Fusion is related to better function and fission, splitting mitochondria into smaller fragments is associated with dysfunction. Have receptors of the membrane of the mitochondria to receive these molecules. Fission driven by drp1 and forms a spiral around mitochondria which constricts the mitochondria and splits them into 2. If overexpress dynamin related protein, mitochondria have fragmented appearance. Inner membrane fusion mediated by opa1 (optic atrophy 1 death and loss of retinal ganglion cells). Mutations of protein associated with neurological long fact disorders. If overexpress mfn+, creates a mass, as lots of mitochondria may fuse together accidentally. Mitochondrial targeted protein derived from coral that turns red when blue light is shined on it. Mitochondria are photo- converted and migrate and as it touches the other mitochondria, the colour can be transferred to another mitochondrion, showing that matrix content is exchanged. If damaged, can"t undergo fusion and will be removed from the cell, as no exchange of matrix proteins occurs.
