Biochemistry 3382A Lecture Notes - Lecture 14: Xanthine, Prophase, Doubling Time

• School: Western University
• Department: Biochemistry
• Course: Biochemistry 3382A
• Professor: Derek Mc Lachlin

Document Summary

Right-handed the turns are in the direction of your right-hand curling into a fist. Major and minor grooves the (cid:373)ajor groo(cid:448)e(cid:859)s tur(cid:374) is further apart tha(cid:374) the (cid:373)i(cid:374)or groo(cid:448)e. 10 bp/turn x 0. 34 nm/bp = 3. 4 nm/turn; 2. 4 nm width. Base tilt = -1. 2o; propeller twist = 16o; helical twist per bp = 36o. Forces influencing nucleic acid structure (rna and dna): base stacking. Van der waals and partial charge interactions act between ring bases. This leads to some base pair combinations having more negative stacking energy which makes them more stable (bonds release more energy when made) the chart is arranged from the lowest to highest stacking energy. At combinations, dna tends to be rich in gc base pairs. C(cid:895) a(cid:374)d t o(cid:374) the (cid:1007)(cid:859) e(cid:374)d (cid:894)thus it pairs with a). In general, the two (cid:272)o(cid:373)ple(cid:373)e(cid:374)tar(cid:455) di(cid:374)u(cid:272)leotide pairs are separated (cid:271)(cid:455) (cid:862):(cid:863) a(cid:374)d ea(cid:272)h pair is (cid:449)ritte(cid:374) fro(cid:373) (cid:1009)(cid:859) to (cid:1007)(cid:859: base pairing.