Biochemistry 3382A Lecture Notes - Lecture 1: Phosphoribosylamine, Pyrimidine, Nucleoside
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Unit 2 Organic Chemistry
Organic compounds vs. Inorganic compounds
What makes a compound organic? Inorganic?
Functional groups (phosphate groups, amino groups, carboxyl groups)
Know the structure of each of these groups, and which organic compounds they are found in. You can draw them for your own use.
Hydrolysis
What is it? What is it used for?
Dehydration synthesis
What is it? What is it used for?
Carbohydrates (Monosaccharides, Disaccharides, Polysaccharides and examples)
Know the process of joining two monosaccharides together to create a disaccharide.
Be able to give examples of several monosaccharides, disaccharides and polysaccharides.
Monosaccharide examples (3) | Disaccharide examples (2) | Complex carbohydrates (3) |
Lipids (Saturated vs. Unsaturated; Phospholipids, Steroids)
Define a saturated fatty acid.
Define an unsaturated fatty acid. Draw if it helps.
What process is used to put the fatty acid chain on a glycerol molecule?
Hydrophilic vs. hydrophobic
Define hydrophilic.
What part of the phospholipid is hydrophilic?
Define hydrophobic.
What part of the phospholipid is hydrophobic?
Proteins, types and functions
What is a protein composed of, and what does it do?
Amino acids
Name the three parts of the amino acid that come off the common Carbon.
Identify each of the three parts. (Amino Acid ID game)
Peptide Bonds
How are they formed?
What two parts of each amino acid do they join together?
Enzymes - define.
Levels of Protein structure
Complete the chart below.
Protein structure level | definition |
Primary | |
Secondary | |
Tertiary | |
Quarternary |
Protein Denaturation
What is it and how does it happen?
Define what a Solute is.
Define what a solvent is
Nucleic acids (DNA, RNA, ATP)
Nucleotide
Name its three parts and be able to identify each of them on a diagram. (Nucleotide ID game)
What are the two possible sugars used in a nucleotide?
Complete the Table below.
DNA | RNA | ATP | |
What sugar does it have? | |||
What nitrogen bases does it have? | |||
Provide the pairings of the nitrogen bases of each nucleic acid | N/A | ||
What is its structure? |
1. | In addition to identifying the genetic material, the experiments of Avery, MacLeod, and McCarty with different strains of Streptococcus pneumoniae demonstrated that | ||||||||||
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2. | In order to show that DNA in cell extracts is responsible for genetic transformation in Streptococcus pneumoniae, important corroborating evidence should indicate that _______ also destroy transforming activity. | ||||||||||
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3. | Based on what you have learned about the experiments conducted by Griffith and Avery and colleagues with bacteria, which of the following would result in transformation of living R cells? | ||||||||||
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4. | A-T base pairs in a DNA double helix | ||||||||||
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5. | If 23 percent of the bases in a sample of double-stranded DNA are adenine, what percentage of the bases are uracil? | ||||||||||
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6. | The uniform diameter of the DNA structure provides evidence for | ||||||||||
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7. | If a sequence of one strand of DNA is 5â²-TGACTATC-3â², what is the complementary strand? | ||||||||||
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8. | What structural aspect of the DNA facilitates dissociation of the two DNA strands for replication? | ||||||||||
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9. | If the MeselsonâStahl density gradient experiment had resulted in two bands of DNA molecules after only one round of replication, one containing only 15N and the second only 14N, this result would have indicated that replication was | ||||||||||
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10. | The nucleoside analogue acyclovir, which is used to treat herpes simplex virus (HSV) infections, lacks a 3â² hydroxyl group (âOH). Predict what will happen if the host cell DNA polymerase incorporates a molecule of acyclovir into an elongating strand of HSV DNA. | ||||||||||
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11. | Which of the following does not demonstrate the stability of the DNA double helix? | ||||||||||
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12. | What effect would a primase inhibitor have on DNA replication? | ||||||||||
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13. | To replicate their DNA in a timely manner, most eukaryotic chromosomes | ||||||||||
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14. | Which statement about DNA replication is false? | ||||||||||
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15. | In many eukaryotes, there are repetitive sequences called telomeres at the ends of chromosomes. After successive rounds of DNA replication, the _______ strand becomes shorter. In some cells, an enzyme called _______ repairs the shortened strand. | ||||||||||
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16. | A researcher studies normal human fibroblast cells. They can be maintained in culture but die off after about 30 cell generations. Unexpectedly, a colony of cells continues to survive and divide past 30 generations. Which scenario is most likely true for these cells? | ||||||||||
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17. | If DNA polymerase III introduces an incorrect nucleotide, what is the first corrective action made by the DNA repair system? | ||||||||||
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18. | Choose the correct order of the following four events in the excision repair of DNA: (1) Base-paired DNA is made complementary to the template. (2) Damaged bases are recognized. (3) DNA ligase seals the new strand to existing DNA. (4) Part of a single strand is excised. | ||||||||||
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19. | Six complete cycles of PCR should result in a _______-fold increase in the amount of DNA. | ||||||||||
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20. | When double-stranded DNA is heated to temperatures above 90°C, it denatures. Denaturation is a process that | ||||||||||
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