Biochemistry 3385A Lecture 8: Dna Repair Defences (Lecture 8)
4 Feb 2015
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Document Summary
Mechanisms and diseases: diseases resulting from dna repair deficiencies. Objectives: identify the type of dna damage repaired by the fa pathway, describe the dna repair deficiency in fanconi anemia, summarize the main steps of the fa repair pathway, identify the repair pathways that cooperate with fa to repair. Dna: state the names the main regulators of the fa pathway, identify the consequences of fa pathway deficiency. Fanconi anemia (fa) is a inherited genomic instability disorder: caused by mutations in genes that regulate replication- dependent removal of interstrand dna crosslinks. Fa pathway: protect cells against a specific type of dna damage: interstrand crosslinks (icl, icl: diepoxybutane (deb). Caused by mitomycin c (mmc) , cisplatin and. Agents causing icl are used as chemotherapeutic agents to treat cancer. Dna interstrand crosslinks (icls) may arise following exposure to environmental mutagens, and are potently toxic when induced in large numbers by chemotherapeutic drugs.
