Biochemistry 3386B Lecture Notes - Lecture 1: Immunoassay, Bioassay, Metabolic Pathway
10 Feb 2020
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Topic: dr. rutledge lecture 1: intro to endocrine. Hormones can be derived from amino acids/proteins/peptides, amines, glycoproteins, or cholesterol. Two main categories: lipid-soluble (steroid, thyroid hormones) and water- soluble (amine, peptide, protein, glycoprotein hormones). Hydrophilic hormones are soluble and do not require carrier proteins while circulating in the bloodstream; they bind receptors on the cell membrane. Hydrophobic hormones require carrier proteins while circulating in the bloodstream; they diffuse directly into cells and bind intracellular receptors. Hydrophobic hormones circulate the blood bound to carrier proteins, such as albumin. Negative feedback: signal induces response, response inhibits signal production. Positive feedback: response feeds back to induce more signal [i. e. estradiol] Inhibitory control: hormone release controlled by inhibitor [i. e. prolactin] Endocrine rhythms: daily, monthly, seasonal rhythms [i. e. cortisol] Over-secretion, under-secretion, and disordered metabolic pathway all classify as endocrine disorders. These disorders affect growth, development, metabolism, fertility, etc.
