Biology 1002B Lecture Notes - Lecture 18: Tumor Suppressor Gene, Colorectal Cancer, Prostate Cancer
21 Apr 2013
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Not winning the war against cancer as proven with death rates. In canada, men are at higher risk to get cancer than women: 40% for women will develop cancer, 45% for men will develop cancer. 28% of men can be expected to die from cancer. Top 4: prostate cancer, breast cancer, lung cancer, colorectal cancer. Cancer is the leading cause of premature death in canada: 25% of canadian can expect to die of cancer, rates among youth are rising. Different cyclins and different cdk at each checkpoint. Expression of proto-oncogenes promotes cell cycling: e. g. egfr. There is no such thing as a cancer gene: oncogenes are not cancer genes, need these genes to function as an embryo. Egfr epidermal growth factor: protein that stimulates growth, receptor that recognizes outside of cell, gene product will stimulate cell division when you are an embryo, proto-oncogenes when deregulated show uncontrolled growth.
