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23 and Me

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Biology 1202B
Brenda Murphy

23 and Me What Can we see in our population?  17% of us are left handed  17% of us have a family history of Multiple Sclerosis  19% of us have a family history of Alzheimer’s Disease  29% of us have a family history of diabetes  56% of us have family history of male pattern baldness  41% of us have a family history of migraines  44% of us have attached earlobes  88% of us have wet earwax  67% of us have a family history of cancer  13% of us have restless leg syndrome  14% of us have perfect pitch  22% of us are lactose intolerant  All of us can smell the asparagus odor in our urine  None of us are world class sprinters  All of us have 23 pairs of chromosomes  In 1956 identified there were 46 chromosomes in a human cell  Homologous chromosomes have same Giemsa binding patterns  New life begins at conception when gametes from maternal egg and paternal sperm join to create a unique human with 46 chromosomes.  46 chromosomes contain 6 billion nucleotides 23 and Me  Privately held Californian company  Personal Genomics and Biotechnology company  Cofounders: Linda Avey and Anne Wojceicki  Wanted to be leaders in understanding human genomic variation  Private Californian company o CLIA certified lab o Developed and offer their test as a service o Do not sell their kit  Spit kit $300 and questionnaires  DNA microarray o Simultaneous analysis of 960,000 SNPs SNPs = Single Nucleotide Polymorphism  SNPs are studied because they have been identified with:  120 disease risks (Alzheimer’s, schizophrenia, Breast or colon cancer)  48 carrier status (Cystic fibrosis, hemacromotis)  57 traits (eye colour, ear wax)  21 drug responses (5’TU, Warfarim) Information 23 and Me Provide  Written report issued in 2 weeks upon receiving your sample  Identified SNP tested and location in a genes  Summaries of your SNP results linked to disease, risk, carrier status, trai
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