Biology 2382B Lecture Notes - Lecture 4: Signal Recognition Particle, Secretion, Microsome
11 Feb 2017
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Typical mammalian cell: 10,000 proteins, must be localized correctly and sent the correct destination. Newly made peptides must be directed to the correct destination. Involves a signal sequence which tells cell to take a protein somewhere (organelle: proteins have a certain sequence that will facilitate movement of that protein to a certain destination. Sorting: related to proteins, not exclusively, in the secretory pathway when you get it to the. Two major protein sorting pathways: secretory and non secretory. General principles of protein synthesis, targeting and sorting. Ribosomes are bound to the membrane of er and protein synthesis continues to occur while the mrna is bound to the ribosome. Many proteins are synthesized just by cytosolic ribosomes: those which remain in the cytosol, those which are targeted to intracellular organelles such as (er), mitochondria, chloroplasts, peroxisomes, and nucleus (they have a specific signal sequence)
