Biology 2382B Lecture Notes - Lecture 12: Apoptosome, Lamin, Aspartic Protease
17 Aug 2018
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Programmed cell death (apoptosis) is a key process. Active cellular process that is morphologically distinct from necrosis (where cells swell and burst) > cells release intercellular contents in an uncontrolled manner: apoptosis: an active process, programmed cell death, things must be turned on and off, frequently involves gene transcription. > but the nucleus starts to break apart into apoptotic bodies. > dna starts to get cut up into pieces and compartmentalized into apoptotic bodies. This is done by dnaase which cuts dna at the end of the histone wrap around site (ie. ~200 bp) so it is cut in a fairly repetitive/specific manner: called internucleosomal sites ie. between the nucleosomes. It takes around 200 dna bp to wrap around a nucleosome (collection of histone proteins) If we were to look at these dna pieces on a gel, we would not see a big smear, but would see these distinct bands at around 200, 400 and.
