Biology 2382B Lecture Notes - Lecture 4: Secretion, Golgi Apparatus, Signal Peptide
24 Oct 2018
School
Department
Course
Professor
Document Summary
Cell bio lecture 4 protein synthesis and transport. Protein sorting/targeting: typical mammalian cell, newly made peptides must be directed to the correct destination, targeting: Direct proteins to the right destinations (organelles) Direct proteins to the secretory pathway (er, golgi, lysosomes). won"t properly. General principles of protein synthesis, targeting and sorting: many proteins are synthesized just by cytosolic ribosomes: Those which are targeted to intracellular organelles such as (er), mitochondria, chloroplasts, peroxisomes, and nucleus (they have a specific signal sequence: other proteins are synthesized by ribosomes attached to er (the rough er): Those which reside in er and proteins which are sorted to pm, golgi complex, and lysosomes: accordingly, two major protein-sorting pathways are known: nonsecretory and secretory, there are two major proteins sorting pathways secretory and non secretory. Proteins that synthesized for secretion are attached to the er: many proteins remain in the cytosol, many are targeted to intracellular organelles such as the er, mitochondria, chloroplasts and nucleus.
