Biology 2382B Lecture Notes - Phosphotransferase, Cystic Fibrosis, Copii
12 Feb 2014
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5: vesicular traffic of proteins & the golgi apparatus. , mediated by vesicles coated with copi proteins, Retrograde recycles the membrane bilayer and certain proteins, such as v-snares and wrongly- sorted er-resident proteins, from the cis-golgi to the er. Important to note is that atp hydrolysis is required for snare proteins to dissociate. It is important to understand that this f508 cftr protein is still functional at the membrane, but sorted incorrectly and is retained in er and degraded. Copi vesicles, bind proteins bearing the kdel sorting signal and returns them to the. Er: this retrieval system prevents depletion of er luminal proteins such as those needed for proper folding of newly-made secretory proteins, the binding affinity of the kdel receptor is very sensitive to ph. The small difference between the ph of the er (higher ph) and that of the golgi (lower ph) favors binding of. Kdel-bearing proteins to the receptor in golgi-derived vesicles and their release in the.
