Biology 2382B Lecture Notes - Lecture 12: Apoptosome, Apaf1, Programmed Cell Death
4 Apr 2016
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Document Summary
Programmed cell death (apoptosis) is a key process. Acive cellular process that is morphologically disinct from necrosis (where cells swell and burst) Big black blobs on apoptoic cell is dna and pieces of the nucleus. Apoptosis makes the cell undergo dramaic morphological changes. Associated with dna condensing; dna-associated protein become more compact. Start to have condensaion of cytoplasm, so cell shrinks a bit. Nuclei start to break apart and form apoptoic bodies. Cell is self-destrucing, but it"s a controlled self-destrucion (analogy: controlled destrucion of a building) Don"t want internal cell components to interact with anything. So by sequestering intracellular components, internal cell debris won"t interact inappropriately with other cells, as it could inappropriately acivate certain things, may be toxic, or may develop anibodies. So split cell into diferent pieces so then phagocyic cell can engulf these apoptoic bodies and further break it down (analogy: take garbage apart, then take it to garbage collector which will break it apart further)
