Biology 2382B Lecture Notes - Lecture 12: Sister Chromatids, Centrosome, Tubulin

• School: Western University
• Department: Biology
• Course: Biology 2382B
• Professor: Sashko Damjanovski

Document Summary

Microtubules 2: tracks for transport other maps vesicle transport (bi-directional) Kinesin, mt"s plus (+) end directed motor protein. Many types: 14 known classes, 45 genes in humans. 2 heavy chains: head + flexible neck + stalk. 2 variable light chains heavy chain heads have atpase activity and mt binding ability light chains recognize cargo. Most are (+) end directed notes: different kinesin types move at different rates linker = neck light chains bind at tail end of heavy chain stalks different light chains recognize different cargo (variable) *if you see kinesin think (+) directed transport. 2 heavy chains, 2 light chains (variable) involved in organelle transport. Kinesin 5 (bipolar) bipolar = both ends the same. 4 heavy chains (pair on each end: no light chains both ends can therefore bind microtubules, involved in microtubule sliding (as heads move towards + ends) Atpase activity involved in mt end disassembly. Kinesin movement anterograde movement: anterograde = forward.