Biology 2581B Lecture Notes - Lecture 13: Centromere, Dosage Compensation, Zygosity
Document Summary
Mutations can occur on a large scale and impact parts of chromosomes and whole genomes. Before genome sequences, genes were analyzed from different organisms to find out their sequence and function. At the sequence level many similarities. Before it was sequenced, they found this out by staining and observing banding patterns. After both genomes were sequenced, they were aligned and similar sequences between the human and mouse genome were found: found many of the genes and large fragments with the same order and type of genes. Each mouse chromosome was (cid:498)pieced together(cid:499) from different human chromosomes. Same information was there in the human genome and mouse but it wasn"t localized to a: but they were on different chromosomes single chromosome, it was on different chromosomes in human chromosomes. There were rearrangements over evolutionary time to account for the differences between mice and human chromosomes: things moved and got pieced together in different ways.