Biology 2581B Lecture Notes - Lecture 19: Gcn4, Myod, Gata1
7 Apr 2013
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A silencer region is just like an enhancer except that it has a negative effect instead of a positive effect. When bound to the silencer, the repressor stops transcription (overrides activation) A silencer can be located thousands of base pairs away from the gene that it is regulating. Silencer binds a negative transacting factor instead of positive. Proteins that binds specific dna elements and inhibit transcription. Block/destabilize rna polymerase assembly and movement by binding to dna sequences very close to the promoter/ farther away (looping) Block activity of transcription factors/ activators by binding to dna-binding region of an activator and preventing it from attaching to an enhancer (competition, quenching) are called corepressor. Repressors have no effect on basal transcription. Repressors can act by interfering with the function of activators: Cis-acting enhancer all cis-acting elements bound by either activators or repressors are referred to as enhancers, even though some may be repressing transcription.
