Biology 2581B Lecture Notes - Lecture 10: Haemophilia B, Genomic Library, Haemophilia A
Document Summary
Finding a gene sequence based on its phenotype can be done with and without mapping information - pedigree: hemophilia a: no mapping information, cystic fibrosis: mapping information was needed. Hemophilia a: old interest: famous historical example, queen victoria, czar, new interest: Haemophilia patients received untested and unscreened clotting factor prior to. 1992: since the blood was untested extreme risk for contracting hiv and hepatitis c. This further increased hiv rates double the bad (hemophilia and hiv: estimated that more than 50% of the haemophilia population contracted hiv from the tainted blood supply in the us along. Normal: connect all the blood cells and seal proteins like fibrin that connect blood cells. Fibrinogen (soluble) not being produced into fibrin (insoluble since it connects and forms the clot) Prothrombin is the coagulation factor, cleaved to make thrombin which helps convert fibrinogen to fibrin. Fibrinogen is soluble and is later converted to fibrin which is not soluble.