Biology 2581B Lecture Notes - Lecture 9: Leucine, Wild Type, Reading Frame

• School: Western University
• Department: Biology
• Course: Biology 2581B
• Professor: Tom Haffie

Document Summary

Could be in the same codon (can be very close) We start out with leucine, suffer a snp, but then we suffer another snp in the same codon that restores leucine: these are 2 independent mutations. If we have a mutation, it throws the reading frame off by one base: but another mutation happens, this time an insertion, we can restore the frame and get our wildtype amino acids back. Mutant suppressant trnas recognize stop codons, they insert an amino acid. Likely impact of given mutations on gene expression. If we have a snp, its effect depends, it might change the meaning of a codon that would then create a different amino acid protein, may or may not influence the phenotype. If the snp creates a stop codon then that creates a protein that"s too short and it"s more likely that it would be a more serious problem and have more dramatic effects on the phenotype.