Biology 3466B Lecture Notes - Lecture 13: Heterozygote Advantage, Genetic Load, Fitness Landscape
14 Oct 2017
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Rh can damage the fetus, and lower fecundity for females. Rh can be subjective to be over dominance. If the population starts with a p value above the equilibrium, selection will abundant the: opposite occurs if the p value is lower than the equilibrium. P (p hat) at the equilibrium = (delta aa delta aa)/2(delta aa-delta aa) Fisher"s theorem: increase in mean fitness strictly equal to genetic variance in fitness. Mean fitness vs. p. mean fitness can vary between 0 and 1 and so can p. selection against recessive. If something against - from (0,0) to (1,1) but arched towards (0,1). (0,0) = trivial equilibrium = kind of obvious and don"t provide information. When the p value is extremely low, the slope of dw/dp is going to steep and is favoured by natural selection. The maximum slope (adaptive landscape) is near (0,0) and the maximum fitness is at (1,1).
