Biology 3466B Lecture Notes - Lecture 19: Coefficient Of Relationship, Zygosity, Monte Carlo Method
14 Oct 2017
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The formula just tells you the probability (what drift should do). In a small population, drift can fix p faster. 1/2ne = frequency of allele that appears in a population & the rate of loss of variance. 4ne = the time required for an allele to fix. Mutation rate (mu) -> 10^-5 and n = 100. 4 (100)(10^-5) is smaller by 10 fold than 1, so the effect of mutation is so small that the noise caused by sampling error will be greater than the signal sent by mutation. The effect of inbreeding is an increasing of autozygosity and decrease in allozygosity. If two alleles are different but make the same phenotype, we call it that they are identical by type. Alleles that are identical by state -> same sequence, but they are not identical by descent. Descent: they came from the same ancestor in the population of study.
