Biology 3592A Lecture Notes - Lecture 21: Oncogene, Gene Expression, Metastasis
29 Nov 2016
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Not necessarily cancer if you have cell proliferation, has to be malignant. Invades blood cells or other cells cell is different then cells it is invading. Benign not terrible (cid:271)ut doesn"t in(cid:448)ade. Huge amount of cell division in development. Chromosomes have to be stable in order to divide. Gene expression proteins involved in proliferation, specialization, apoptosis etc necessary for global homeostasis. In cancer we see chromosome instability, deficits, weird chromosome copy numbers, methylation and histone modification changes. Uncontrolled proliferation, improper cell cycle check points, cell death. In any given tumor you will have a number of these things occurring (epigenetic modifications, histone probs etc) Gonna be different, even within one tumor. Driver mutations: mutations leading to improperness mutations responsible for uncontrolled cell growth. Passenger mutation: mutations that do not lead to uncontrolled cell growth but due to driver mutations occur could affect phenotype of tumor but not growth.
