Biology 1001A Lecture Notes - Lecture 2: Zoonosis, Hiv, Integrase
20 Sep 2016
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Document Summary
Hiv occurs worldwide, but not all areas equally affected. This is because this area is ground-zero for origin (originates from chimps and other primates). This is called siv in chimps and primates. Hiv-1m was acquired from siv-infected chimp in 1908. Can use graph to estimate when virus first spread to human hosts. >12 independent spillovers (different strains of hiv) from primates to humans. In general, antiviral drugs have worse side effects than antibacterial, antifungals. No virus life cycle can be targeted without killing host cell. Good news and bad news about retroviruses (such as hiv) Retroviruses has reverse transcriptase and codes for reverse transcription. No proofreading in reverse transcription = more genetic errors. This disobeys central dogma of molecular biology. The greater amount of mutations helps hiv (harder to kill, different structures) To minimize side effects of antiviral drugs, attack virus-specific steps) Grabs onto receptors of white blood cell. New virions assemble, bud or bust out, and enter bloodstream.
